heart valve diseases

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	190
interventional	114
Observational	58
Registry	18

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Device	36
Drug	29
Procedure	21
Other	10
Drug|placebo	5
Behavioral	4
Device|Other	2
Behavioral|Procedure	1
Biological|Device|Genetic|Procedure	1
Biological|Procedure	1
Diagnostic Test	1
Dietary Supplement	1
Drug|Other	1
Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	17
China	13
Korea, Republic of	10
Canada	7
NA	6
Russian Federation	6
Spain	5
Brazil	4
Denmark	4
France	4
Sweden	4
Egypt	2
France|Germany|Italy	2
Switzerland	2
United Kingdom	2
United States|Canada	2
Australia|Austria|Belgium|Canada|France|Germany|Hungary|Israel|Italy|Netherlands|Romania|Spain|Turkey|United Kingdom	1
Austria	1
Austria|Belgium|France|Germany|Italy|Netherlands|Portugal|Switzerland	1
Austria|Finland|France|Germany|Ireland|Italy|Netherlands|Sweden|Switzerland|United Kingdom	1
Austria|Germany|Poland|Switzerland|United Kingdom	1
Belgium|Germany|Netherlands|Switzerland	1
Canada|Denmark|Germany|Italy|Netherlands|Spain	1
Czech Republic	1
Denmark|Finland|Iceland|Norway|Sweden	1
Finland	1
Germany	1
Germany|Italy|Netherlands|Portugal	1
Germany|United States|Canada|Denmark|Netherlands|Sweden|Switzerland	1
India	1
Iran, Islamic Republic of	1
Lithuania	1
Mexico	1
Portugal	1
Thailand	1
United States|Canada|Netherlands|Norway|Sweden	1
United States|France|Greece|Poland|United Kingdom	1
United States|Germany|Netherlands|New Zealand	1
United States|Poland	1
United States|Puerto Rico|Spain	1

Sites per Study

Site_count	Study_Count
1	82
2	2
3	1
4	2
6	3
7	1
8	1
9	1
10	3
11	1
12	2
13	1
14	2
15	1
18	1
19	1
22	1
25	2
26	1
32	1
34	1
43	1
45	1
47	1

Phase

Phase	Study_Count
N/A	78
Phase 4	15
Phase 2	10
Phase 1/Phase 2	4
Phase 3	4
Early Phase 1	1
Phase 1	1
Phase 2/Phase 3	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	31
2	60
3	13
4	3
5	1
6	1
NA	5

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	20	11.0000	98	30.00	42.00	1100	58.00	2.0
1st Qu.	20	40.0000	98	79.50	96.50	1100	104.50	52.0
Median	20	93.5000	98	109.00	128.50	1100	170.00	92.0
Mean	20	265.4231	98	116.25	226.30	1100	157.25	124.4
3rd Qu.	20	265.5000	98	145.75	225.75	1100	222.75	166.5
Max.	20	2000.0000	98	217.00	1005.00	1100	231.00	464.0

Trial Group Type

group_type	Group_Count
Experimental	95
Active Comparator	56
Other	24
No Intervention	23
Placebo Comparator	14
NA	5
Sham Comparator	1

Intervention Model

intervention_model	Study_Count
Parallel Assignment	77
Single Group Assignment	34
Crossover Assignment	1
Factorial Assignment	1
NA	1

Primary Purpose

primary_purpose	Study_Count
Treatment	64
Prevention	29
Diagnostic	6
Supportive Care	6
Basic Science	4
Other	2
Screening	2
Health Services Research	1

Observational Studies

Studies by Country

Country	Study_Count
United States	15
Korea, Republic of	6
NA	5
China	4
France	3
Germany	3
Spain	3
Denmark	2
Sweden	2
United Kingdom	2
Belgium|Czechia|Germany|Italy|Netherlands|United Kingdom	1
Belgium|France|Germany|Italy|Moldova, Republic of|Netherlands|Switzerland|United Kingdom	1
Belgium|Germany|Italy|Netherlands|Spain|Switzerland|United Kingdom	1
Belgium|Italy|Netherlands|United Kingdom	1
Czechia|France|Germany|Italy|Netherlands|United Kingdom	1
Egypt	1
Japan	1
Netherlands	1
Switzerland	1
Taiwan	1
Turkey	1
United States|Germany|Poland	1
United States|Korea, Republic of|Taiwan	1

Sites per Study

Site_count	Study_Count
1	44
2	1
4	2
5	2
7	4
8	2
9	2
12	1

Enrollment Metrics

Measure	Observational
Min	5.000
1st Qu	100.000
Median	189.500
Mean	6980.052
3rd Qu	868.000
Max	273365.000

Observation Model

observational_model	Study_Count
Cohort	33
Case-Only	8
Case-Control	6
Other	4
Case Control	3
Defined Population	1
Defined Population, Natural History	1
Ecologic or Community	1
NA	1

Time Perspective

time_perspective	Study_Count
Prospective	39
Retrospective	12
Cross-Sectional	5
Cross-Sectional, Retrospective/Prospective	1
Longitudinal, Prospective	1

Registries

Studies by Country

Country	Study_Count
United States	4
Austria	2
Belgium	2
China	2
Germany	2
Canada	1
France	1
France|Germany|Italy|Lithuania|Switzerland	1
Italy	1
Netherlands	1
United Kingdom	1

Sites per Study

Site_count	Study_Count
1	14
3	2
4	1
7	1

Enrollment Metrics

Measure	Registries
Min	1.000
1st Qu	200.000
Median	450.000
Mean	2612.222
3rd Qu	4250.000
Max	15410.000

Registry Model

observational_model	Study_Count
Cohort	15
Case-Only	3

Time Perspective

time_perspective	Study_Count
Prospective	16
Other	2

Follow-up

target_duration	Study_Count
1 Year	4
10 Years	4
2 Years	3
1 Day	1
24 Months	1
3 Years	1
30 Years	1
5 Years	1
7 Days	1
90 Days	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03280745	Hypertonic Saline for Fluid Resuscitation After Cardiac Surgery	https://ClinicalTrials.gov/show/NCT03280745	Completed	University Hospital Inselspital, Berne	2019-05-27
NCT03674593	Clinical and Fundamental Aspects of Prosthetics and Translocation of Mitral Valve Chordae	https://ClinicalTrials.gov/show/NCT03674593	Active, not recruiting	Tomsk National Research Medical Center of the Russian Academy of Sciences	2021-09-01
NCT03366649	Improving Mitral Repair for Functional Mitral Regurgitation	https://ClinicalTrials.gov/show/NCT03366649	Recruiting	Emory University	2023-12-31
NCT03825250	The Val-CARD Trial	https://ClinicalTrials.gov/show/NCT03825250	Recruiting	University of Leicester	2021-11-30
NCT03142152	The CARILLON Trial - Assessment of the Carillon® Mitral Contour System® in Treating Functional Mitral Regurgitation Associated With Heart Failure	https://ClinicalTrials.gov/show/NCT03142152	Active, not recruiting	Cardiac Dimensions Pty Ltd	2022-10-01
NCT03053778	Individualised Follow-up After Valve Surgery	https://ClinicalTrials.gov/show/NCT03053778	Completed	Odense University Hospital	2018-06-02
NCT02982850	Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Atrial Fibrillation Associated With Valvular Disease	https://ClinicalTrials.gov/show/NCT02982850	Active, not recruiting	Asan Medical Center	2020-10-31
NCT02981953	TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System	https://ClinicalTrials.gov/show/NCT02981953	Completed	Edwards Lifesciences	2018-01-01
NCT02867930	Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography	https://ClinicalTrials.gov/show/NCT02867930	Completed	Postgraduate Institute of Medical Education and Research, Chandigarh	2016-12-31
NCT02825134	Comparison of Transcatheter Versus Surgical Aortic Valve Replacement in Younger Low Surgical Risk Patients With Severe Aortic Stenosis	https://ClinicalTrials.gov/show/NCT02825134	Recruiting	Rigshospitalet, Denmark	2020-06-30
NCT02775123	Cytokine Clearance With Cytoabsorbant Device During Cardiac Bypass	https://ClinicalTrials.gov/show/NCT02775123	Completed	Centre Hospitalier Universitaire Vaudois	2018-01-31
NCT02747485	Impact of Diffuse Myocardial Fibrosis on the Ventricular Function in Regurgitant Left-Sided Valve Heart Diseases ( The DIFFUsE Study)	https://ClinicalTrials.gov/show/NCT02747485	Recruiting	Assistance Publique Hopitaux De Marseille	2020-08-31
NCT02726087	Quality of Life After Ministernotomy Versus Full Sternotomy Aortic Valve Replacement	https://ClinicalTrials.gov/show/NCT02726087	Completed	Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud	2019-05-20
NCT02720549	The Effect of Remote Ischemic Postconditioning on Postoperative Renal Dysfunction in Patients Undergoing Valvular Heart Surgery	https://ClinicalTrials.gov/show/NCT02720549	Completed	Yonsei University	2017-04-14
NCT02703311	REPAIR - transcatheteR rEPair of mitrAl Insufficiency With caRdioband System	https://ClinicalTrials.gov/show/NCT02703311	Completed	Edwards Lifesciences	2017-11-30
NCT02679261	Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic Valve	https://ClinicalTrials.gov/show/NCT02679261	Active, not recruiting	Hospital Universitari Vall d’Hebron Research Institute	2020-10-31
NCT02673697	Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement	https://ClinicalTrials.gov/show/NCT02673697	Active, not recruiting	LivaNova	2019-10-31
NCT02671474	Valve Leaflet Motion in Sutureless Bioprosthetic Aortic Valves	https://ClinicalTrials.gov/show/NCT02671474	Completed	Karolinska University Hospital	2016-03-31
NCT02657109	Influence of a Rehabilitation in Valve Replacement on Heart Rate Variability and Oxidative Stress	https://ClinicalTrials.gov/show/NCT02657109	Completed	Universidade Metodista de Piracicaba	2015-03-31
NCT02587039	An Intervention to Reduce Delirium After Cardiac Surgery	https://ClinicalTrials.gov/show/NCT02587039	Completed	Johns Hopkins University	2015-12-31
NCT03632967	Early Feasibility Study of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System	https://ClinicalTrials.gov/show/NCT03632967	Recruiting	4Tech Cardio Ltd.	2021-02-28
NCT02237495	Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)	https://ClinicalTrials.gov/show/NCT02237495	Completed	Xijing Hospital	2017-03-01
NCT03398733	CPAP Treatment and Postoperative Outcomes in Patients With Rheumatic Valvular Heart Disease	https://ClinicalTrials.gov/show/NCT03398733	Completed	Nanjing Medical University	2019-12-01
NCT02479581	The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass	https://ClinicalTrials.gov/show/NCT02479581	Completed	Xiangya Hospital of Central South University	2016-11-30
NCT02370511	Mitral Implantation of TRAnscatheter vaLves	https://ClinicalTrials.gov/show/NCT02370511	Active, not recruiting	Mayo Clinic	2022-12-31
NCT02303795	RIvaroxaban for Valvular Heart diseasE and atRial Fibrillation Trial -RIVER Trial	https://ClinicalTrials.gov/show/NCT02303795	Active, not recruiting	Hospital do Coracao	2019-12-31
NCT02297334	Removal of Cytokines During Extracorporeal Circulation in Cardiac Surgery	https://ClinicalTrials.gov/show/NCT02297334	Completed	Universitätsklinikum Hamburg-Eppendorf	2015-10-31
NCT02272621	Surgical Trauma After Partial Upper Hemisternotomy Versus Full Sternotomy Aortic Valve Replacement	https://ClinicalTrials.gov/show/NCT02272621	Completed	Karolinska University Hospital	2018-03-31
NCT02249000	BIOVALVE - I / II Clincial Investigation	https://ClinicalTrials.gov/show/NCT02249000	Active, not recruiting	Biotronik AG	2018-03-31
NCT02173860	Strategies for Revascularization in Patients Undergoing Heart Valve Surgery With Concomitant Coronary Artery Disease	https://ClinicalTrials.gov/show/NCT02173860	Recruiting	Portuguese Society of Cardiology	2021-01-31
NCT02136979	Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery	https://ClinicalTrials.gov/show/NCT02136979	Completed	Konkuk University Medical Center	2016-12-31
NCT02084069	Atrovastatin for Preventing Atrial Fibrillation Following Open Cardiac Valve Repair	https://ClinicalTrials.gov/show/NCT02084069	Completed	Urmia University of Medical Sciences	2014-04-30
NCT01312779	Magna Mitral - 23mm	https://ClinicalTrials.gov/show/NCT01312779	Completed	Edwards Lifesciences	2018-11-30
NCT01296074	Corticosteroid Prophylaxis on the Cardiopulmonary Bypass-Induced Systemic Inflammatory Response	https://ClinicalTrials.gov/show/NCT01296074	Completed	Beijing Anzhen Hospital	2011-04-30
NCT01276444	Comparison of Goal-directed Algorithms of Hemodynamic Therapy After Combined Valve Repair	https://ClinicalTrials.gov/show/NCT01276444	Completed	Northern State Medical University	2010-08-31
NCT03646760	The Improving ATTENDance to Cardiac Rehabilitation Trial	https://ClinicalTrials.gov/show/NCT03646760	Recruiting	Henry Ford Health System	2023-03-31
NCT01972555	Cardiac Function After Minimally Invasive Aortic Valve Implantation	https://ClinicalTrials.gov/show/NCT01972555	Completed	Karolinska University Hospital	2015-07-31
NCT01826149	Propofol Effects on Mitral Valve Annular Velocity	https://ClinicalTrials.gov/show/NCT01826149	Completed	Konkuk University Medical Center	2015-12-31
NCT01825720	Effect of Glucose-Insulin-Potassium on Hyperlactatemia in Patients Undergoing Valvular Heart Surgery	https://ClinicalTrials.gov/show/NCT01825720	Completed	Yonsei University	2013-05-31
NCT01819012	Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery	https://ClinicalTrials.gov/show/NCT01819012	Completed	Konkuk University Medical Center	2013-11-30
NCT01812174	On-X Heart Valve - 17mm Aortic and 23mm Mitral	https://ClinicalTrials.gov/show/NCT01812174	Recruiting	On-X Life Technologies, Inc.	2021-12-31
NCT01802619	Prevention of Renal Failure by Nitric Oxide in Prolonged Cardiopulmonary Bypass.	https://ClinicalTrials.gov/show/NCT01802619	Completed	Xijing Hospital	2015-06-30
NCT01783483	An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative Recovery	https://ClinicalTrials.gov/show/NCT01783483	Completed	Zimmer Biomet	2015-06-30
NCT01704482	N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement	https://ClinicalTrials.gov/show/NCT01704482	Completed	Assiut University	2012-09-30
NCT01685554	Normothermiс Cardiopulmonary Bypass Increases Cerebral Oxygenation During Valve Surgery	https://ClinicalTrials.gov/show/NCT01685554	Completed	Northern State Medical University	2011-12-31
NCT01681095	Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent	https://ClinicalTrials.gov/show/NCT01681095	Completed	William Beaumont Hospitals	2014-08-31
NCT01653223	Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery	https://ClinicalTrials.gov/show/NCT01653223	Recruiting	Sun Yat-sen University	2022-12-31
NCT01591018	SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry	https://ClinicalTrials.gov/show/NCT01591018	Completed	University Hospital Ostrava	2014-12-31
NCT01559610	Preoperatively Orientation in Cardiac Surgery: Nurses Intervention on Patients Recovery	https://ClinicalTrials.gov/show/NCT01559610	Completed	Instituto de Cardiologia do Rio Grande do Sul	2009-03-31
NCT01558765	CopenHeartVR - Integrated Rehabilitation of Patients After Heart Valve Surgery	https://ClinicalTrials.gov/show/NCT01558765	Completed	Rigshospitalet, Denmark	2015-05-31
NCT01524354	Depth of Anesthesia in Cardiac Surgery	https://ClinicalTrials.gov/show/NCT01524354	Completed	Northern State Medical University	2011-12-31
NCT01514162	Post-Approval Study Protocol of the St. Jude Medical Trifecta Valve	https://ClinicalTrials.gov/show/NCT01514162	Completed	Abbott Medical Devices	2014-10-31
NCT01511991	Sevoflurane’s Effect on Mitral Valve Annular Velocity in Cardiac Surgery	https://ClinicalTrials.gov/show/NCT01511991	Completed	Konkuk University Medical Center	2014-05-31
NCT01495949	The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone	https://ClinicalTrials.gov/show/NCT01495949	Completed	Mahidol University	2013-12-31
NCT01477151	Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery	https://ClinicalTrials.gov/show/NCT01477151	Completed	Lawson Health Research Institute	2015-03-31
NCT01427621	Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery	https://ClinicalTrials.gov/show/NCT01427621	Completed	Yonsei University	2010-11-30
NCT01426776	Effect of Heart Valve Replacement on Cheyne-Stokes Respiration	https://ClinicalTrials.gov/show/NCT01426776	Completed	Nanjing Medical University	2012-02-29
NCT01416792	Centrifugation vs. Multiple-pass Hemofiltration of the Residual Cardiopulmonary Bypass Volume	https://ClinicalTrials.gov/show/NCT01416792	Completed	University of Saskatchewan	2012-09-30
NCT01384643	Effect of Propofol on Renal Injury in Patients Undergoing Valvular Heart Surgery	https://ClinicalTrials.gov/show/NCT01384643	Completed	Yonsei University	2012-05-31
NCT01348074	Reinitiation of Anticoagulation After Temporary Withdrawal of Vitamin K Antagonist	https://ClinicalTrials.gov/show/NCT01348074	Completed	McMaster University	2013-12-31
NCT01338961	Normothermia Versus Hypothermia for Valvular Surgery Patients	https://ClinicalTrials.gov/show/NCT01338961	Completed	Meshalkin Research Institute of Pathology of Circulation	2013-01-31
NCT04160130	RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis)	https://ClinicalTrials.gov/show/NCT04160130	Recruiting	SSS International Clinical Research GmbH	2021-02-28
NCT04442100	The Study of Biological Prosthetic Heart Valves With the “Easy Change” System	https://ClinicalTrials.gov/show/NCT04442100	Recruiting	Tomsk National Research Medical Center of the Russian Academy of Sciences	2026-12-31
NCT04254315	OPTIMA: Psychological Distress and the Effect of Intensive Group Based Cognitive Therapy in Patients With Newly Diagnosed Ischemic Heart Disease	https://ClinicalTrials.gov/show/NCT04254315	Recruiting	University Hospital Bispebjerg and Frederiksberg	2020-12-31
NCT04234087	Feasibility and Effectiveness of an Additional Resistance and Balance Training in Cardiac Rehabilitation of Older Patients After Valve Surgery or Intervention	https://ClinicalTrials.gov/show/NCT04234087	Active, not recruiting	Lithuanian University of Health Sciences	2020-02-29
NCT04223219	Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University	https://ClinicalTrials.gov/show/NCT04223219	Recruiting	Mansoura University	2021-06-30
NCT04221490	2019-06 TRISCEND Study	https://ClinicalTrials.gov/show/NCT04221490	Recruiting	Edwards Lifesciences	2025-10-31
NCT04055883	Clinical Study to Evaluate Efficacy and Safety of DA-1229 in Patients With CAVD	https://ClinicalTrials.gov/show/NCT04055883	Recruiting	Dong-A ST Co., Ltd.	2022-12-31
NCT04030494	Validation Study of an Advanced Blood Pressure Monitor	https://ClinicalTrials.gov/show/NCT04030494	Completed	Withings	2019-06-13
NCT04015973	The PRE-OP ENERGY Trial	https://ClinicalTrials.gov/show/NCT04015973	Recruiting	University of Leicester	2022-04-30
NCT04011501	Erector Spinae Plane Block for Minimal Invasive Cardiac Surgery (Heart-Port).	https://ClinicalTrials.gov/show/NCT04011501	Recruiting	Hospital Clinic of Barcelona	2019-09-01
NCT03977129	Quantitative Flow Ratio (QFR) Guided Revascularization Strategy for Patients Undergoing Primary Valve Surgery With Comorbid Coronary Artery Disease	https://ClinicalTrials.gov/show/NCT03977129	Recruiting	Ruijin Hospital	2022-08-31
NCT03911661	Fearon Algorithm in Warfarin Patient Self-Management	https://ClinicalTrials.gov/show/NCT03911661	Recruiting	University of Utah	2020-04-30
NCT03885180	Randomized Evaluation of D-dimer Guiding dUration of Oral antiCoagulation thErapy	https://ClinicalTrials.gov/show/NCT03885180	Recruiting	Wuhan Asia Heart Hospital	2021-03-01
NCT03810820	Remote ECG Monitoring of TAVI Patients	https://ClinicalTrials.gov/show/NCT03810820	Recruiting	Population Health Research Institute	2020-01-30
NCT03799133	Safety and Efficacy of the Gastric Reactance (XL) in Patients Post-operated of Elective Cardiac Surgery	https://ClinicalTrials.gov/show/NCT03799133	Completed	Critical Perfusion Inc.	2019-12-28
NCT03786965	Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures.	https://ClinicalTrials.gov/show/NCT03786965	Recruiting	St. Petersburg State Pavlov Medical University	2025-07-20
NCT03753126	Stent Geometry in Sutureless Bioprosthetic Valves	https://ClinicalTrials.gov/show/NCT03753126	Completed	Karolinska University Hospital	2018-11-30
NCT03709511	Post Cardiac Valvular Surgery Rehabilitation	https://ClinicalTrials.gov/show/NCT03709511	Recruiting	Guangdong Provincial People’s Hospital	2020-12-30
NCT03696446	E-health Intervention for Cardiac Rehabilitation	https://ClinicalTrials.gov/show/NCT03696446	Recruiting	Ottawa Heart Institute Research Corporation	2021-06-01
NCT03661398	Caisson Transcatheter Mitral Valve Replacement (TMVR)	https://ClinicalTrials.gov/show/NCT03661398	Active, not recruiting	Caisson Interventional LLC	2020-08-31
NCT03635424	Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study	https://ClinicalTrials.gov/show/NCT03635424	Active, not recruiting	Medtronic Cardiovascular	2019-11-13
NCT03541213	Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer)	https://ClinicalTrials.gov/show/NCT03541213	Recruiting	University Hospital, Angers	2020-06-30
NCT03527381	Nitric Oxide in Cardiopulmonary Bypass for Renal Protection in Cardiac Surgery	https://ClinicalTrials.gov/show/NCT03527381	Completed	Tomsk National Research Medical Center of the Russian Academy of Sciences	2016-12-25
NCT03474159	Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve (BAV) by Multimodal Imaging (MRI, Echocardiography and Ultrafast Ultrasound Imaging)	https://ClinicalTrials.gov/show/NCT03474159	Recruiting	French Cardiology Society	2023-08-31
NCT03466606	Implementation of a Trimodal Prehabilitation Program as a Preoperative Optimization Strategy in Cardiac Surgery	https://ClinicalTrials.gov/show/NCT03466606	Recruiting	Hospital Clinic of Barcelona	2020-06-30
NCT03433274	Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation	https://ClinicalTrials.gov/show/NCT03433274	Recruiting	Abbott Medical Devices	2022-06-30
NCT01210976	The Effects of Levosimendan on Haemodynamics in Patients Undergoing Elective Aortic Valve Replacement (AVR)Together With Coronary Artery Bypass Grafting (CABG) Surgery	https://ClinicalTrials.gov/show/NCT01210976	Completed	Tampere University Hospital	2010-09-30
NCT01178710	Effect of Simvastatin on Cardiac Function	https://ClinicalTrials.gov/show/NCT01178710	Completed	Sun Yat-sen University	2011-06-30
NCT01175681	Effect of Remote Ischemia Preconditioning on Myocardial Injury in Patients Undergoing Heart Valve Surgery	https://ClinicalTrials.gov/show/NCT01175681	Completed	Sun Yat-sen University	2011-03-31
NCT01174719	Humanalbumin, Hydroxyethylstarch and Ringer Lactate During Cardiac Surgery	https://ClinicalTrials.gov/show/NCT01174719	Completed	Medical University of Vienna	2010-02-28
NCT01144546	Passive Leg Raising Test to Predict Hypotension During Induction of Anesthesia in Patients Undergoing Cardiac Surgery	https://ClinicalTrials.gov/show/NCT01144546	Completed	Seoul National University Hospital	2009-09-30
NCT01116024	ATS 3f Enable(tm) Aortic Bioprosthesis, Model 6000	https://ClinicalTrials.gov/show/NCT01116024	Completed	Medtronic Cardiovascular	2010-12-31
NCT01023152	Effect of Remote Ischemic Preconditioning on Acute Kidney Injury in Patients Undergoing Heart Valve Replacement Surgery With Cardiopulmonary Bypass	https://ClinicalTrials.gov/show/NCT01023152	Completed	Yonsei University	NA
NCT00978588	Comparison of 6% Hydroxyethyl Starch 130/0.4 With 5% Albumin as Priming Solution for Cardiopulmonary Bypass	https://ClinicalTrials.gov/show/NCT00978588	Completed	Yonsei University	2008-12-31
NCT00876525	Clinical Investigation of the Freedom SOLO Stentless Heart Valve	https://ClinicalTrials.gov/show/NCT00876525	Completed	LivaNova	2013-12-31
NCT00862043	Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease	https://ClinicalTrials.gov/show/NCT00862043	Completed	Hospital General Universitario Gregorio Marañon	2016-07-31
NCT03539458	Feasibility Study of the Tendyne Mitral Valve System for Use in Subjects With Mitral Annular Calcification	https://ClinicalTrials.gov/show/NCT03539458	Active, not recruiting	Abbott Medical Devices	2019-10-28
NCT03225612	Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS)	https://ClinicalTrials.gov/show/NCT03225612	Recruiting	Mitralign, Inc.	2018-06-30
NCT02732691	THE ALIGN-AS TRIAL: JenaValve Pericardial TAVR Aortic Stenosis Study	https://ClinicalTrials.gov/show/NCT02732691	Enrolling by invitation	JenaValve Technology, Inc.	2020-09-30
NCT03839654	Loop Gain in the Reversion of OSA Treated by Either CPAP or Cardiac Valve Replacement	https://ClinicalTrials.gov/show/NCT03839654	Recruiting	Nanjing Medical University	2023-06-30
NCT00721136	Randomized Study of the Use of Warfarin During Pacemaker or ICD Implantation in Patients Requiring Long Term Anticoagulation	https://ClinicalTrials.gov/show/NCT00721136	Completed	Johns Hopkins University	2010-08-31
NCT00688571	Melody Transcatheter Pulmonary Valve (TPV) Post-Market Surveillance Study	https://ClinicalTrials.gov/show/NCT00688571	Completed	Medtronic Cardiovascular	2014-12-31
NCT00639782	Prospective Randomized On-X Versus SJM Evaluation Trial	https://ClinicalTrials.gov/show/NCT00639782	Active, not recruiting	On-X Life Technologies, Inc.	2021-09-30
NCT00630916	Clinical Investigation Of The Mitroflow Aortic Pericardial Heart Valve	https://ClinicalTrials.gov/show/NCT00630916	Completed	Sorin Group USA, Inc.	2005-12-31
NCT00581399	A Randomized Multicenter Clinical Study On the High Vacuum Body Cavity Drainage System Following Open Heart Surgery	https://ClinicalTrials.gov/show/NCT00581399	Completed	University of California, Irvine	2010-07-31
NCT00377871	Hemodynamic Performance in Stentless Heart Valves	https://ClinicalTrials.gov/show/NCT00377871	Completed	University of Aarhus	2010-01-31
NCT00371891	Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS)	https://ClinicalTrials.gov/show/NCT00371891	Completed	St. Joseph’s Healthcare Hamilton	2009-06-30
NCT00370643	Glucose Control in Open Heart Surgery	https://ClinicalTrials.gov/show/NCT00370643	Completed	University of Sao Paulo	NA
NCT00356759	Prolongation of the Interval Between Monitoring of Warfarin in Stable Patients	https://ClinicalTrials.gov/show/NCT00356759	Completed	McMaster University	2010-01-31
NCT00329667	Observational Study of Prosthetic Tissue Aortic and Mitral Heart Valve	https://ClinicalTrials.gov/show/NCT00329667	Completed	Abbott Medical Devices	2006-03-31
NCT00291525	Randomized On-X Anticoagulation Trial	https://ClinicalTrials.gov/show/NCT00291525	Active, not recruiting	On-X Life Technologies, Inc.	2020-12-31
NCT02833948	Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)	https://ClinicalTrials.gov/show/NCT02833948	Completed	ECRI bv	2018-12-31
NCT00166400	A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation.	https://ClinicalTrials.gov/show/NCT00166400	Completed	Mayo Clinic	2007-07-31

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03376165	Post-Operative Myocardial Incident & Atrial Fibrillation	https://ClinicalTrials.gov/show/NCT03376165	Recruiting	University Hospital, Lille	2028-01-31
NCT03826264	Transpacific TAVR Registry	https://ClinicalTrials.gov/show/NCT03826264	Recruiting	Asan Medical Center	2022-12-31
NCT03248232	Assessments of Thrombus Formation in TAVI	https://ClinicalTrials.gov/show/NCT03248232	Completed	Kumamoto University	2018-04-30
NCT03239509	15 Years Outcomes Following Bioprosthetic vs Mechanical Aortic Valve Replacement Between 50-65 Years	https://ClinicalTrials.gov/show/NCT03239509	Completed	Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud	2018-04-30
NCT03197051	Impact of Perioperative Shedding of the Endothelial Glycocalyx on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery.	https://ClinicalTrials.gov/show/NCT03197051	Completed	Yonsei University	2018-07-11
NCT03163836	Concomitant Surgical Atrial Fibrillation Ablation in Double Valve Replacement	https://ClinicalTrials.gov/show/NCT03163836	Recruiting	Guangzhou General Hospital of Guangzhou Military Command	2023-03-10
NCT03139721	Medtronic HAMMOCK Post Approval Study	https://ClinicalTrials.gov/show/NCT03139721	Active, not recruiting	Medtronic Cardiovascular	2019-05-17
NCT03015025	Pharmacogenetic Dosage Algorithm for Acenocoumarol	https://ClinicalTrials.gov/show/NCT03015025	Completed	Instituto de Investigación Hospital Universitario La Paz	2013-10-31
NCT02981004	PAR I - Patient-to-Annulus Relation I	https://ClinicalTrials.gov/show/NCT02981004	Completed	Abbott Medical Devices	2017-12-18
NCT02898090	Development and Validation of Automated Indicators on the Appropriateness of Oral Anticoagulant Prescriptions	https://ClinicalTrials.gov/show/NCT02898090	Recruiting	University Hospital, Bordeaux	2020-04-30
NCT02790008	Magnetic Resonance Imaging and Fibrosis	https://ClinicalTrials.gov/show/NCT02790008	Recruiting	Linkoeping University	2019-12-31
NCT02727413	Inflammatory Mediator Profiles During Heart Valve Replacement Surgery	https://ClinicalTrials.gov/show/NCT02727413	Completed	Jena University Hospital	2017-02-28
NCT02527629	Aortic Replacement Using Individualised Regenerative Allografts - ARISE (the “Surveillance”)	https://ClinicalTrials.gov/show/NCT02527629	Completed	corlife	2019-01-31
NCT02490644	Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Valvular Heart Surgery	https://ClinicalTrials.gov/show/NCT02490644	Completed	Yonsei University	2017-09-29
NCT02394184	The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement Registry	https://ClinicalTrials.gov/show/NCT02394184	Completed	Asan Medical Center	2019-09-24
NCT02371863	Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR	https://ClinicalTrials.gov/show/NCT02371863	Completed	UMC Utrecht	2015-12-31
NCT02266251	Optimizing Health Outcomes in Patients With Symptomatic Aortic Valve Disease	https://ClinicalTrials.gov/show/NCT02266251	Completed	Duke University	2017-04-30
NCT02035540	European Clinical Study for the Application of Regenerative Heart Valves - ESPOIR	https://ClinicalTrials.gov/show/NCT02035540	Completed	corlife	2017-01-31
NCT04454177	SMART Watch Facilitated Early Discharge in Patients Undergoing Transcatheter Aortic Valve Replacement	https://ClinicalTrials.gov/show/NCT04454177	Recruiting	Second Affiliated Hospital, School of Medicine, Zhejiang University	2021-08-31
NCT01996657	D-Dimer Determined Anticoagulation INTENSITY in Patients With Mechanical Valve Replacement	https://ClinicalTrials.gov/show/NCT01996657	Completed	Wuhan Asia Heart Hospital	2016-05-31
NCT01760668	Aortopathy in Persons With Bicuspid Aortic Valve, Turner and Marfan Syndrome	https://ClinicalTrials.gov/show/NCT01760668	Completed	University of Aarhus	2015-10-31
NCT01676727	ADVANCE Direct Aortic Study	https://ClinicalTrials.gov/show/NCT01676727	Completed	Medtronic Cardiovascular	2014-04-30
NCT01669551	A Phase 1 Feasbility Study Of Volume Intracardiac Echo In Assessment Of Patients With Structural And Valvular Heart Disease Undergoing Percutaneous Transcatheter Therapy	https://ClinicalTrials.gov/show/NCT01669551	Completed	University of Pennsylvania	2014-12-31
NCT01624870	CoreValve Advance-II Study: Prospective International Post-market Study	https://ClinicalTrials.gov/show/NCT01624870	Completed	Medtronic Cardiovascular	2013-10-31
NCT01476995	Prognostic Indicators as Provided by the EPIC ClearView	https://ClinicalTrials.gov/show/NCT01476995	Completed	Epic Research & Diagnostics, Inc.	2011-06-30
NCT01428947	Does Coronary Angiography Cause Cognitive Dysfunction?	https://ClinicalTrials.gov/show/NCT01428947	Completed	Karolinska Institutet	2012-06-30
NCT01322165	National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions	https://ClinicalTrials.gov/show/NCT01322165	Completed	National Heart, Lung, and Blood Institute (NHLBI)	2015-09-30
NCT04126018	Comparative Imaging Assessment of Valvular Heart Disease	https://ClinicalTrials.gov/show/NCT04126018	Recruiting	The Cleveland Clinic	2022-06-30
NCT04083118	Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride	https://ClinicalTrials.gov/show/NCT04083118	Recruiting	University of Edinburgh	2021-08-03
NCT04080219	The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery	https://ClinicalTrials.gov/show/NCT04080219	Recruiting	Yonsei University	2021-12-31
NCT04068740	Personalised Decision Support for Heart Valve Disease	https://ClinicalTrials.gov/show/NCT04068740	Completed	German Heart Institute	2019-01-31
NCT04068337	Freestyle Prosthesis for Aortic Root-replacement With and Without Hemiarch Replacement	https://ClinicalTrials.gov/show/NCT04068337	Completed	Triemli Hospital	2019-03-01
NCT04067635	Primary Mitral Regurgitation Repair	https://ClinicalTrials.gov/show/NCT04067635	Enrolling by invitation	The Methodist Hospital System	2021-06-30
NCT04024566	Rapid Non-invasive Detection of Aortic Stenosis	https://ClinicalTrials.gov/show/NCT04024566	Recruiting	Avicena LLC	2021-05-31
NCT03935178	Evaluating Right Ventricular (RV) Size and Function Using the Upper Valley RV Algorithm and Novel Imaging Modalities	https://ClinicalTrials.gov/show/NCT03935178	Recruiting	Dartmouth-Hitchcock Medical Center	2020-06-30
NCT03836521	Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry	https://ClinicalTrials.gov/show/NCT03836521	Recruiting	Cedars-Sinai Medical Center	2028-08-15
NCT03724123	Machine Learning-Based Risk Profile Classification of Patients Undergoing Elective Heart Valve Surgery	https://ClinicalTrials.gov/show/NCT03724123	Completed	Kepler University Hospital	2014-12-31
NCT03669666	Phase Contrast in Valvular Heart Disease	https://ClinicalTrials.gov/show/NCT03669666	Completed	Assiut University	2018-06-30
NCT03664102	Automated Fastener Device Versus Manually Tied Knot in MiAVR	https://ClinicalTrials.gov/show/NCT03664102	Completed	Centre Hospitalier La Chartreuse	2018-09-01
NCT03595423	SPAnish Aortic VALVE Multicentric Study	https://ClinicalTrials.gov/show/NCT03595423	Recruiting	Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud	2019-03-31
NCT03590730	Benefits of ICD for the Primary Prevention in Patients With Valvular Cardiomyopathy	https://ClinicalTrials.gov/show/NCT03590730	Recruiting	Keimyung University Dongsan Medical Center	2020-11-15
NCT03458806	Phono- and Electrocardiogram Assisted Detection of Valvular Disease	https://ClinicalTrials.gov/show/NCT03458806	Active, not recruiting	University of California, San Francisco	2020-12-31
NCT03440697	Pathogenetic Basis of Aortopathy and Aortic Valve Disease	https://ClinicalTrials.gov/show/NCT03440697	Recruiting	Indiana University	2025-12-31
NCT01213615	Hancock II Ultra Porcine Bioprosthesis Hemodynamic Study	https://ClinicalTrials.gov/show/NCT01213615	Completed	Medtronic Cardiovascular	2013-10-31
NCT01194362	A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve Disease	https://ClinicalTrials.gov/show/NCT01194362	Active, not recruiting	Baylor Research Institute	2020-12-31
NCT01178502	PGx Study to Develop and Validate the Predictive Warfarin Dosing Algorithm for Personalized Warfarin Pharmacotherapy	https://ClinicalTrials.gov/show/NCT01178502	Completed	Inje University	2010-04-30
NCT01076296	A Post-Marketing Study for On Label Evaluation of the GE Vscan Ultrasound Imaging System	https://ClinicalTrials.gov/show/NCT01076296	Completed	GE Healthcare	2012-07-31
NCT01052948	The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events	https://ClinicalTrials.gov/show/NCT01052948	Completed	Pfizer	2009-12-31
NCT03011697	Valvular Heart Disease Registry Study in Second Affiliated Hospital of ZheJiang University	https://ClinicalTrials.gov/show/NCT03011697	Recruiting	Second Affiliated Hospital, School of Medicine, Zhejiang University	2026-12-31
NCT04445012	Cardiovascular Acoustics and an Intelligent Stethoscope	https://ClinicalTrials.gov/show/NCT04445012	Recruiting	Papworth Hospital NHS Foundation Trust	2021-09-30
NCT00745810	Anesthetic Management and Remote Reperfusion Injuries	https://ClinicalTrials.gov/show/NCT00745810	Completed	National Taiwan University Hospital	2010-11-30
NCT00629902	Heart Valve Prosthesis-Patient Mismatch	https://ClinicalTrials.gov/show/NCT00629902	Completed	Florence Nightingale Hospital, Istanbul	2008-05-31
NCT00412386	Abnormal 3-D MRI Flow Patterns in Adolescents Patients With Bicuspid Aortic Valve	https://ClinicalTrials.gov/show/NCT00412386	Completed	Emory University	NA
NCT00362401	Patients Perception of Mechanical Heart Valve Sounds: Psychoacoustics and Quality of Life	https://ClinicalTrials.gov/show/NCT00362401	Completed	University of Aarhus	NA
NCT00359489	Methods Study to Evaluate Use of Cardiac Ultrasound to Assess Heart Valve Abnormality in People.	https://ClinicalTrials.gov/show/NCT00359489	Completed	Pfizer	NA
NCT00234364	Pergolide Treatment and Valvular Heart Disease	https://ClinicalTrials.gov/show/NCT00234364	Completed	Ã…rhus Amt	NA
NCT00226265	The Short Form-36: Pre- Versus Post-Surgical Administration in Cardiac Surgery Patients	https://ClinicalTrials.gov/show/NCT00226265	Completed	Weill Medical College of Cornell University	2006-12-31
NCT00202657	Observational Study of Heart Valve Disease in Patients With Parkinson’s Disease Treated With Pergolide	https://ClinicalTrials.gov/show/NCT00202657	Completed	Société Française de Cardiologie	NA

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03372512	Fluid Status and T1-mapping by CMR	https://ClinicalTrials.gov/show/NCT03372512	Recruiting	Medical University of Vienna	2020-12-15
NCT03371394	Fluid Status in Valvular Heart Disease	https://ClinicalTrials.gov/show/NCT03371394	Recruiting	Medical University of Vienna	2020-12-01
NCT02974218	Saint Luc Valve Registry	https://ClinicalTrials.gov/show/NCT02974218	Recruiting	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	2020-01-31
NCT02925819	Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery	https://ClinicalTrials.gov/show/NCT02925819	Recruiting	French Cardiology Society	2020-12-31
NCT02806310	Podocan and Wnt Pathway in the Development of Aortopathy in Bicuspid Valve Disease	https://ClinicalTrials.gov/show/NCT02806310	Active, not recruiting	Bassett Healthcare	2020-06-30
NCT02692833	Telomere Biology and AKI in Cardiac Surgery	https://ClinicalTrials.gov/show/NCT02692833	Completed	Queen Mary University of London	2017-05-31
NCT02219984	START-Register: Survey on Anticoagulated Patients Register	https://ClinicalTrials.gov/show/NCT02219984	Recruiting	St. Orsola Hospital	2023-07-31
NCT01823432	Genetic Risks for Bicuspid Aortic Valve Disease	https://ClinicalTrials.gov/show/NCT01823432	Recruiting	The University of Texas Health Science Center, Houston	2021-05-31
NCT01784055	NeoChord TACT Post-Market Surveillance Registry	https://ClinicalTrials.gov/show/NCT01784055	Completed	NeoChord	2016-07-31
NCT01756222	Bicuspid Aortic Valve (BAV) Registry	https://ClinicalTrials.gov/show/NCT01756222	Recruiting	University of Michigan	2030-12-31
NCT04190602	Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System	https://ClinicalTrials.gov/show/NCT04190602	Recruiting	NeoChord	2021-12-31
NCT04047082	Online Videodensitometric Assessment of Aortic Regurgitation in the Cath-Lab	https://ClinicalTrials.gov/show/NCT04047082	Recruiting	Imperial College London	2019-09-30
NCT03797820	Multicenter Registry Study of Aortic Valve Stenosis in Zhejiang Elderly（Mrs AVS）	https://ClinicalTrials.gov/show/NCT03797820	Recruiting	Second Affiliated Hospital, School of Medicine, Zhejiang University	2023-09-30
NCT03709693	Clinical Outcomes in Patients Treated With SternaLock Blu	https://ClinicalTrials.gov/show/NCT03709693	Recruiting	Zimmer Biomet	2026-01-01
NCT03674788	The Prospective LEUVEN Transcatheter Valve Therapy Registry	https://ClinicalTrials.gov/show/NCT03674788	Recruiting	Universitaire Ziekenhuizen Leuven	2037-12-31
NCT03488732	Valvular Heart Disease Registry	https://ClinicalTrials.gov/show/NCT03488732	Recruiting	Technische Universität München	2025-01-01
NCT03488420	Canadian EdoxAban(Lixiana®) Registry in Patients With ATrial Fibrillation/Flutter With Confirmed ValvUlar HeaRt DiseasE	https://ClinicalTrials.gov/show/NCT03488420	Recruiting	Montreal Heart Institute	2021-03-01
NCT03484806	Registration and Cohort Study of Valvular Heart Disease in Adults in China	https://ClinicalTrials.gov/show/NCT03484806	Recruiting	China National Center for Cardiovascular Diseases	2020-09-01