Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 190
interventional 114
Observational 58
Registry 18

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Device 36
Drug 29
Procedure 21
Other 10
Drug|placebo 5
Behavioral 4
Device|Other 2
Behavioral|Procedure 1
Biological|Device|Genetic|Procedure 1
Biological|Procedure 1
Diagnostic Test 1
Dietary Supplement 1
Drug|Other 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 17
China 13
Korea, Republic of 10
Canada 7
NA 6
Russian Federation 6
Spain 5
Brazil 4
Denmark 4
France 4
Sweden 4
Egypt 2
France|Germany|Italy 2
Switzerland 2
United Kingdom 2
United States|Canada 2
Australia|Austria|Belgium|Canada|France|Germany|Hungary|Israel|Italy|Netherlands|Romania|Spain|Turkey|United Kingdom 1
Austria 1
Austria|Belgium|France|Germany|Italy|Netherlands|Portugal|Switzerland 1
Austria|Finland|France|Germany|Ireland|Italy|Netherlands|Sweden|Switzerland|United Kingdom 1
Austria|Germany|Poland|Switzerland|United Kingdom 1
Belgium|Germany|Netherlands|Switzerland 1
Canada|Denmark|Germany|Italy|Netherlands|Spain 1
Czech Republic 1
Denmark|Finland|Iceland|Norway|Sweden 1
Finland 1
Germany 1
Germany|Italy|Netherlands|Portugal 1
Germany|United States|Canada|Denmark|Netherlands|Sweden|Switzerland 1
India 1
Iran, Islamic Republic of 1
Lithuania 1
Mexico 1
Portugal 1
Thailand 1
United States|Canada|Netherlands|Norway|Sweden 1
United States|France|Greece|Poland|United Kingdom 1
United States|Germany|Netherlands|New Zealand 1
United States|Poland 1
United States|Puerto Rico|Spain 1

Sites per Study

Site_count Study_Count
1 82
2 2
3 1
4 2
6 3
7 1
8 1
9 1
10 3
11 1
12 2
13 1
14 2
15 1
18 1
19 1
22 1
25 2
26 1
32 1
34 1
43 1
45 1
47 1

Phase

Phase Study_Count
N/A 78
Phase 4 15
Phase 2 10
Phase 1/Phase 2 4
Phase 3 4
Early Phase 1 1
Phase 1 1
Phase 2/Phase 3 1

Number of Arms

Number_of_Arms Count_of_Studies
1 31
2 60
3 13
4 3
5 1
6 1
NA 5

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 20 11.0000 98 30.00 42.00 1100 58.00 2.0
1st Qu. 20 40.0000 98 79.50 96.50 1100 104.50 52.0
Median 20 93.5000 98 109.00 128.50 1100 170.00 92.0
Mean 20 265.4231 98 116.25 226.30 1100 157.25 124.4
3rd Qu. 20 265.5000 98 145.75 225.75 1100 222.75 166.5
Max. 20 2000.0000 98 217.00 1005.00 1100 231.00 464.0

Trial Group Type

group_type Group_Count
Experimental 95
Active Comparator 56
Other 24
No Intervention 23
Placebo Comparator 14
NA 5
Sham Comparator 1

Intervention Model

intervention_model Study_Count
Parallel Assignment 77
Single Group Assignment 34
Crossover Assignment 1
Factorial Assignment 1
NA 1

Primary Purpose

primary_purpose Study_Count
Treatment 64
Prevention 29
Diagnostic 6
Supportive Care 6
Basic Science 4
Other 2
Screening 2
Health Services Research 1

Observational Studies

Studies by Country

Country Study_Count
United States 15
Korea, Republic of 6
NA 5
China 4
France 3
Germany 3
Spain 3
Denmark 2
Sweden 2
United Kingdom 2
Belgium|Czechia|Germany|Italy|Netherlands|United Kingdom 1
Belgium|France|Germany|Italy|Moldova, Republic of|Netherlands|Switzerland|United Kingdom 1
Belgium|Germany|Italy|Netherlands|Spain|Switzerland|United Kingdom 1
Belgium|Italy|Netherlands|United Kingdom 1
Czechia|France|Germany|Italy|Netherlands|United Kingdom 1
Egypt 1
Japan 1
Netherlands 1
Switzerland 1
Taiwan 1
Turkey 1
United States|Germany|Poland 1
United States|Korea, Republic of|Taiwan 1

Sites per Study

Site_count Study_Count
1 44
2 1
4 2
5 2
7 4
8 2
9 2
12 1

Enrollment Metrics

Measure Observational
Min 5.000
1st Qu 100.000
Median 189.500
Mean 6980.052
3rd Qu 868.000
Max 273365.000

Observation Model

observational_model Study_Count
Cohort 33
Case-Only 8
Case-Control 6
Other 4
Case Control 3
Defined Population 1
Defined Population, Natural History 1
Ecologic or Community 1
NA 1

Time Perspective

time_perspective Study_Count
Prospective 39
Retrospective 12
Cross-Sectional 5
Cross-Sectional, Retrospective/Prospective 1
Longitudinal, Prospective 1

Registries

Studies by Country

Country Study_Count
United States 4
Austria 2
Belgium 2
China 2
Germany 2
Canada 1
France 1
France|Germany|Italy|Lithuania|Switzerland 1
Italy 1
Netherlands 1
United Kingdom 1

Sites per Study

Site_count Study_Count
1 14
3 2
4 1
7 1

Enrollment Metrics

Measure Registries
Min 1.000
1st Qu 200.000
Median 450.000
Mean 2612.222
3rd Qu 4250.000
Max 15410.000

Registry Model

observational_model Study_Count
Cohort 15
Case-Only 3

Time Perspective

time_perspective Study_Count
Prospective 16
Other 2

Follow-up

target_duration Study_Count
1 Year 4
10 Years 4
2 Years 3
1 Day 1
24 Months 1
3 Years 1
30 Years 1
5 Years 1
7 Days 1
90 Days 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03280745 Hypertonic Saline for Fluid Resuscitation After Cardiac Surgery https://ClinicalTrials.gov/show/NCT03280745 Completed University Hospital Inselspital, Berne 2019-05-27
NCT03674593 Clinical and Fundamental Aspects of Prosthetics and Translocation of Mitral Valve Chordae https://ClinicalTrials.gov/show/NCT03674593 Active, not recruiting Tomsk National Research Medical Center of the Russian Academy of Sciences 2021-09-01
NCT03366649 Improving Mitral Repair for Functional Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03366649 Recruiting Emory University 2023-12-31
NCT03825250 The Val-CARD Trial https://ClinicalTrials.gov/show/NCT03825250 Recruiting University of Leicester 2021-11-30
NCT03142152 The CARILLON Trial - Assessment of the Carillon® Mitral Contour System® in Treating Functional Mitral Regurgitation Associated With Heart Failure https://ClinicalTrials.gov/show/NCT03142152 Active, not recruiting Cardiac Dimensions Pty Ltd 2022-10-01
NCT03053778 Individualised Follow-up After Valve Surgery https://ClinicalTrials.gov/show/NCT03053778 Completed Odense University Hospital 2018-06-02
NCT02982850 Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Atrial Fibrillation Associated With Valvular Disease https://ClinicalTrials.gov/show/NCT02982850 Active, not recruiting Asan Medical Center 2020-10-31
NCT02981953 TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System https://ClinicalTrials.gov/show/NCT02981953 Completed Edwards Lifesciences 2018-01-01
NCT02867930 Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography https://ClinicalTrials.gov/show/NCT02867930 Completed Postgraduate Institute of Medical Education and Research, Chandigarh 2016-12-31
NCT02825134 Comparison of Transcatheter Versus Surgical Aortic Valve Replacement in Younger Low Surgical Risk Patients With Severe Aortic Stenosis https://ClinicalTrials.gov/show/NCT02825134 Recruiting Rigshospitalet, Denmark 2020-06-30
NCT02775123 Cytokine Clearance With Cytoabsorbant Device During Cardiac Bypass https://ClinicalTrials.gov/show/NCT02775123 Completed Centre Hospitalier Universitaire Vaudois 2018-01-31
NCT02747485 Impact of Diffuse Myocardial Fibrosis on the Ventricular Function in Regurgitant Left-Sided Valve Heart Diseases ( The DIFFUsE Study) https://ClinicalTrials.gov/show/NCT02747485 Recruiting Assistance Publique Hopitaux De Marseille 2020-08-31
NCT02726087 Quality of Life After Ministernotomy Versus Full Sternotomy Aortic Valve Replacement https://ClinicalTrials.gov/show/NCT02726087 Completed Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud 2019-05-20
NCT02720549 The Effect of Remote Ischemic Postconditioning on Postoperative Renal Dysfunction in Patients Undergoing Valvular Heart Surgery https://ClinicalTrials.gov/show/NCT02720549 Completed Yonsei University 2017-04-14
NCT02703311 REPAIR - transcatheteR rEPair of mitrAl Insufficiency With caRdioband System https://ClinicalTrials.gov/show/NCT02703311 Completed Edwards Lifesciences 2017-11-30
NCT02679261 Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic Valve https://ClinicalTrials.gov/show/NCT02679261 Active, not recruiting Hospital Universitari Vall d’Hebron Research Institute 2020-10-31
NCT02673697 Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement https://ClinicalTrials.gov/show/NCT02673697 Active, not recruiting LivaNova 2019-10-31
NCT02671474 Valve Leaflet Motion in Sutureless Bioprosthetic Aortic Valves https://ClinicalTrials.gov/show/NCT02671474 Completed Karolinska University Hospital 2016-03-31
NCT02657109 Influence of a Rehabilitation in Valve Replacement on Heart Rate Variability and Oxidative Stress https://ClinicalTrials.gov/show/NCT02657109 Completed Universidade Metodista de Piracicaba 2015-03-31
NCT02587039 An Intervention to Reduce Delirium After Cardiac Surgery https://ClinicalTrials.gov/show/NCT02587039 Completed Johns Hopkins University 2015-12-31
NCT03632967 Early Feasibility Study of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System https://ClinicalTrials.gov/show/NCT03632967 Recruiting 4Tech Cardio Ltd. 2021-02-28
NCT02237495 Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS) https://ClinicalTrials.gov/show/NCT02237495 Completed Xijing Hospital 2017-03-01
NCT03398733 CPAP Treatment and Postoperative Outcomes in Patients With Rheumatic Valvular Heart Disease https://ClinicalTrials.gov/show/NCT03398733 Completed Nanjing Medical University 2019-12-01
NCT02479581 The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass https://ClinicalTrials.gov/show/NCT02479581 Completed Xiangya Hospital of Central South University 2016-11-30
NCT02370511 Mitral Implantation of TRAnscatheter vaLves https://ClinicalTrials.gov/show/NCT02370511 Active, not recruiting Mayo Clinic 2022-12-31
NCT02303795 RIvaroxaban for Valvular Heart diseasE and atRial Fibrillation Trial -RIVER Trial https://ClinicalTrials.gov/show/NCT02303795 Active, not recruiting Hospital do Coracao 2019-12-31
NCT02297334 Removal of Cytokines During Extracorporeal Circulation in Cardiac Surgery https://ClinicalTrials.gov/show/NCT02297334 Completed Universitätsklinikum Hamburg-Eppendorf 2015-10-31
NCT02272621 Surgical Trauma After Partial Upper Hemisternotomy Versus Full Sternotomy Aortic Valve Replacement https://ClinicalTrials.gov/show/NCT02272621 Completed Karolinska University Hospital 2018-03-31
NCT02249000 BIOVALVE - I / II Clincial Investigation https://ClinicalTrials.gov/show/NCT02249000 Active, not recruiting Biotronik AG 2018-03-31
NCT02173860 Strategies for Revascularization in Patients Undergoing Heart Valve Surgery With Concomitant Coronary Artery Disease https://ClinicalTrials.gov/show/NCT02173860 Recruiting Portuguese Society of Cardiology 2021-01-31
NCT02136979 Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery https://ClinicalTrials.gov/show/NCT02136979 Completed Konkuk University Medical Center 2016-12-31
NCT02084069 Atrovastatin for Preventing Atrial Fibrillation Following Open Cardiac Valve Repair https://ClinicalTrials.gov/show/NCT02084069 Completed Urmia University of Medical Sciences 2014-04-30
NCT01312779 Magna Mitral - 23mm https://ClinicalTrials.gov/show/NCT01312779 Completed Edwards Lifesciences 2018-11-30
NCT01296074 Corticosteroid Prophylaxis on the Cardiopulmonary Bypass-Induced Systemic Inflammatory Response https://ClinicalTrials.gov/show/NCT01296074 Completed Beijing Anzhen Hospital 2011-04-30
NCT01276444 Comparison of Goal-directed Algorithms of Hemodynamic Therapy After Combined Valve Repair https://ClinicalTrials.gov/show/NCT01276444 Completed Northern State Medical University 2010-08-31
NCT03646760 The Improving ATTENDance to Cardiac Rehabilitation Trial https://ClinicalTrials.gov/show/NCT03646760 Recruiting Henry Ford Health System 2023-03-31
NCT01972555 Cardiac Function After Minimally Invasive Aortic Valve Implantation https://ClinicalTrials.gov/show/NCT01972555 Completed Karolinska University Hospital 2015-07-31
NCT01826149 Propofol Effects on Mitral Valve Annular Velocity https://ClinicalTrials.gov/show/NCT01826149 Completed Konkuk University Medical Center 2015-12-31
NCT01825720 Effect of Glucose-Insulin-Potassium on Hyperlactatemia in Patients Undergoing Valvular Heart Surgery https://ClinicalTrials.gov/show/NCT01825720 Completed Yonsei University 2013-05-31
NCT01819012 Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery https://ClinicalTrials.gov/show/NCT01819012 Completed Konkuk University Medical Center 2013-11-30
NCT01812174 On-X Heart Valve - 17mm Aortic and 23mm Mitral https://ClinicalTrials.gov/show/NCT01812174 Recruiting On-X Life Technologies, Inc. 2021-12-31
NCT01802619 Prevention of Renal Failure by Nitric Oxide in Prolonged Cardiopulmonary Bypass. https://ClinicalTrials.gov/show/NCT01802619 Completed Xijing Hospital 2015-06-30
NCT01783483 An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative Recovery https://ClinicalTrials.gov/show/NCT01783483 Completed Zimmer Biomet 2015-06-30
NCT01704482 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement https://ClinicalTrials.gov/show/NCT01704482 Completed Assiut University 2012-09-30
NCT01685554 Normothermiс Cardiopulmonary Bypass Increases Cerebral Oxygenation During Valve Surgery https://ClinicalTrials.gov/show/NCT01685554 Completed Northern State Medical University 2011-12-31
NCT01681095 Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent https://ClinicalTrials.gov/show/NCT01681095 Completed William Beaumont Hospitals 2014-08-31
NCT01653223 Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery https://ClinicalTrials.gov/show/NCT01653223 Recruiting Sun Yat-sen University 2022-12-31
NCT01591018 SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry https://ClinicalTrials.gov/show/NCT01591018 Completed University Hospital Ostrava 2014-12-31
NCT01559610 Preoperatively Orientation in Cardiac Surgery: Nurses Intervention on Patients Recovery https://ClinicalTrials.gov/show/NCT01559610 Completed Instituto de Cardiologia do Rio Grande do Sul 2009-03-31
NCT01558765 CopenHeartVR - Integrated Rehabilitation of Patients After Heart Valve Surgery https://ClinicalTrials.gov/show/NCT01558765 Completed Rigshospitalet, Denmark 2015-05-31
NCT01524354 Depth of Anesthesia in Cardiac Surgery https://ClinicalTrials.gov/show/NCT01524354 Completed Northern State Medical University 2011-12-31
NCT01514162 Post-Approval Study Protocol of the St. Jude Medical Trifecta Valve https://ClinicalTrials.gov/show/NCT01514162 Completed Abbott Medical Devices 2014-10-31
NCT01511991 Sevoflurane’s Effect on Mitral Valve Annular Velocity in Cardiac Surgery https://ClinicalTrials.gov/show/NCT01511991 Completed Konkuk University Medical Center 2014-05-31
NCT01495949 The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone https://ClinicalTrials.gov/show/NCT01495949 Completed Mahidol University 2013-12-31
NCT01477151 Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery https://ClinicalTrials.gov/show/NCT01477151 Completed Lawson Health Research Institute 2015-03-31
NCT01427621 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery https://ClinicalTrials.gov/show/NCT01427621 Completed Yonsei University 2010-11-30
NCT01426776 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration https://ClinicalTrials.gov/show/NCT01426776 Completed Nanjing Medical University 2012-02-29
NCT01416792 Centrifugation vs. Multiple-pass Hemofiltration of the Residual Cardiopulmonary Bypass Volume https://ClinicalTrials.gov/show/NCT01416792 Completed University of Saskatchewan 2012-09-30
NCT01384643 Effect of Propofol on Renal Injury in Patients Undergoing Valvular Heart Surgery https://ClinicalTrials.gov/show/NCT01384643 Completed Yonsei University 2012-05-31
NCT01348074 Reinitiation of Anticoagulation After Temporary Withdrawal of Vitamin K Antagonist https://ClinicalTrials.gov/show/NCT01348074 Completed McMaster University 2013-12-31
NCT01338961 Normothermia Versus Hypothermia for Valvular Surgery Patients https://ClinicalTrials.gov/show/NCT01338961 Completed Meshalkin Research Institute of Pathology of Circulation 2013-01-31
NCT04160130 RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis) https://ClinicalTrials.gov/show/NCT04160130 Recruiting SSS International Clinical Research GmbH 2021-02-28
NCT04442100 The Study of Biological Prosthetic Heart Valves With the “Easy Change” System https://ClinicalTrials.gov/show/NCT04442100 Recruiting Tomsk National Research Medical Center of the Russian Academy of Sciences 2026-12-31
NCT04254315 OPTIMA: Psychological Distress and the Effect of Intensive Group Based Cognitive Therapy in Patients With Newly Diagnosed Ischemic Heart Disease https://ClinicalTrials.gov/show/NCT04254315 Recruiting University Hospital Bispebjerg and Frederiksberg 2020-12-31
NCT04234087 Feasibility and Effectiveness of an Additional Resistance and Balance Training in Cardiac Rehabilitation of Older Patients After Valve Surgery or Intervention https://ClinicalTrials.gov/show/NCT04234087 Active, not recruiting Lithuanian University of Health Sciences 2020-02-29
NCT04223219 Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University https://ClinicalTrials.gov/show/NCT04223219 Recruiting Mansoura University 2021-06-30
NCT04221490 2019-06 TRISCEND Study https://ClinicalTrials.gov/show/NCT04221490 Recruiting Edwards Lifesciences 2025-10-31
NCT04055883 Clinical Study to Evaluate Efficacy and Safety of DA-1229 in Patients With CAVD https://ClinicalTrials.gov/show/NCT04055883 Recruiting Dong-A ST Co., Ltd. 2022-12-31
NCT04030494 Validation Study of an Advanced Blood Pressure Monitor https://ClinicalTrials.gov/show/NCT04030494 Completed Withings 2019-06-13
NCT04015973 The PRE-OP ENERGY Trial https://ClinicalTrials.gov/show/NCT04015973 Recruiting University of Leicester 2022-04-30
NCT04011501 Erector Spinae Plane Block for Minimal Invasive Cardiac Surgery (Heart-Port). https://ClinicalTrials.gov/show/NCT04011501 Recruiting Hospital Clinic of Barcelona 2019-09-01
NCT03977129 Quantitative Flow Ratio (QFR) Guided Revascularization Strategy for Patients Undergoing Primary Valve Surgery With Comorbid Coronary Artery Disease https://ClinicalTrials.gov/show/NCT03977129 Recruiting Ruijin Hospital 2022-08-31
NCT03911661 Fearon Algorithm in Warfarin Patient Self-Management https://ClinicalTrials.gov/show/NCT03911661 Recruiting University of Utah 2020-04-30
NCT03885180 Randomized Evaluation of D-dimer Guiding dUration of Oral antiCoagulation thErapy https://ClinicalTrials.gov/show/NCT03885180 Recruiting Wuhan Asia Heart Hospital 2021-03-01
NCT03810820 Remote ECG Monitoring of TAVI Patients https://ClinicalTrials.gov/show/NCT03810820 Recruiting Population Health Research Institute 2020-01-30
NCT03799133 Safety and Efficacy of the Gastric Reactance (XL) in Patients Post-operated of Elective Cardiac Surgery https://ClinicalTrials.gov/show/NCT03799133 Completed Critical Perfusion Inc. 2019-12-28
NCT03786965 Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures. https://ClinicalTrials.gov/show/NCT03786965 Recruiting St. Petersburg State Pavlov Medical University 2025-07-20
NCT03753126 Stent Geometry in Sutureless Bioprosthetic Valves https://ClinicalTrials.gov/show/NCT03753126 Completed Karolinska University Hospital 2018-11-30
NCT03709511 Post Cardiac Valvular Surgery Rehabilitation https://ClinicalTrials.gov/show/NCT03709511 Recruiting Guangdong Provincial People’s Hospital 2020-12-30
NCT03696446 E-health Intervention for Cardiac Rehabilitation https://ClinicalTrials.gov/show/NCT03696446 Recruiting Ottawa Heart Institute Research Corporation 2021-06-01
NCT03661398 Caisson Transcatheter Mitral Valve Replacement (TMVR) https://ClinicalTrials.gov/show/NCT03661398 Active, not recruiting Caisson Interventional LLC 2020-08-31
NCT03635424 Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study https://ClinicalTrials.gov/show/NCT03635424 Active, not recruiting Medtronic Cardiovascular 2019-11-13
NCT03541213 Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer) https://ClinicalTrials.gov/show/NCT03541213 Recruiting University Hospital, Angers 2020-06-30
NCT03527381 Nitric Oxide in Cardiopulmonary Bypass for Renal Protection in Cardiac Surgery https://ClinicalTrials.gov/show/NCT03527381 Completed Tomsk National Research Medical Center of the Russian Academy of Sciences 2016-12-25
NCT03474159 Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve (BAV) by Multimodal Imaging (MRI, Echocardiography and Ultrafast Ultrasound Imaging) https://ClinicalTrials.gov/show/NCT03474159 Recruiting French Cardiology Society 2023-08-31
NCT03466606 Implementation of a Trimodal Prehabilitation Program as a Preoperative Optimization Strategy in Cardiac Surgery https://ClinicalTrials.gov/show/NCT03466606 Recruiting Hospital Clinic of Barcelona 2020-06-30
NCT03433274 Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03433274 Recruiting Abbott Medical Devices 2022-06-30
NCT01210976 The Effects of Levosimendan on Haemodynamics in Patients Undergoing Elective Aortic Valve Replacement (AVR)Together With Coronary Artery Bypass Grafting (CABG) Surgery https://ClinicalTrials.gov/show/NCT01210976 Completed Tampere University Hospital 2010-09-30
NCT01178710 Effect of Simvastatin on Cardiac Function https://ClinicalTrials.gov/show/NCT01178710 Completed Sun Yat-sen University 2011-06-30
NCT01175681 Effect of Remote Ischemia Preconditioning on Myocardial Injury in Patients Undergoing Heart Valve Surgery https://ClinicalTrials.gov/show/NCT01175681 Completed Sun Yat-sen University 2011-03-31
NCT01174719 Humanalbumin, Hydroxyethylstarch and Ringer Lactate During Cardiac Surgery https://ClinicalTrials.gov/show/NCT01174719 Completed Medical University of Vienna 2010-02-28
NCT01144546 Passive Leg Raising Test to Predict Hypotension During Induction of Anesthesia in Patients Undergoing Cardiac Surgery https://ClinicalTrials.gov/show/NCT01144546 Completed Seoul National University Hospital 2009-09-30
NCT01116024 ATS 3f Enable(tm) Aortic Bioprosthesis, Model 6000 https://ClinicalTrials.gov/show/NCT01116024 Completed Medtronic Cardiovascular 2010-12-31
NCT01023152 Effect of Remote Ischemic Preconditioning on Acute Kidney Injury in Patients Undergoing Heart Valve Replacement Surgery With Cardiopulmonary Bypass https://ClinicalTrials.gov/show/NCT01023152 Completed Yonsei University NA
NCT00978588 Comparison of 6% Hydroxyethyl Starch 130/0.4 With 5% Albumin as Priming Solution for Cardiopulmonary Bypass https://ClinicalTrials.gov/show/NCT00978588 Completed Yonsei University 2008-12-31
NCT00876525 Clinical Investigation of the Freedom SOLO Stentless Heart Valve https://ClinicalTrials.gov/show/NCT00876525 Completed LivaNova 2013-12-31
NCT00862043 Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease https://ClinicalTrials.gov/show/NCT00862043 Completed Hospital General Universitario Gregorio Marañon 2016-07-31
NCT03539458 Feasibility Study of the Tendyne Mitral Valve System for Use in Subjects With Mitral Annular Calcification https://ClinicalTrials.gov/show/NCT03539458 Active, not recruiting Abbott Medical Devices 2019-10-28
NCT03225612 Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) https://ClinicalTrials.gov/show/NCT03225612 Recruiting Mitralign, Inc. 2018-06-30
NCT02732691 THE ALIGN-AS TRIAL: JenaValve Pericardial TAVR Aortic Stenosis Study https://ClinicalTrials.gov/show/NCT02732691 Enrolling by invitation JenaValve Technology, Inc. 2020-09-30
NCT03839654 Loop Gain in the Reversion of OSA Treated by Either CPAP or Cardiac Valve Replacement https://ClinicalTrials.gov/show/NCT03839654 Recruiting Nanjing Medical University 2023-06-30
NCT00721136 Randomized Study of the Use of Warfarin During Pacemaker or ICD Implantation in Patients Requiring Long Term Anticoagulation https://ClinicalTrials.gov/show/NCT00721136 Completed Johns Hopkins University 2010-08-31
NCT00688571 Melody Transcatheter Pulmonary Valve (TPV) Post-Market Surveillance Study https://ClinicalTrials.gov/show/NCT00688571 Completed Medtronic Cardiovascular 2014-12-31
NCT00639782 Prospective Randomized On-X Versus SJM Evaluation Trial https://ClinicalTrials.gov/show/NCT00639782 Active, not recruiting On-X Life Technologies, Inc. 2021-09-30
NCT00630916 Clinical Investigation Of The Mitroflow Aortic Pericardial Heart Valve https://ClinicalTrials.gov/show/NCT00630916 Completed Sorin Group USA, Inc. 2005-12-31
NCT00581399 A Randomized Multicenter Clinical Study On the High Vacuum Body Cavity Drainage System Following Open Heart Surgery https://ClinicalTrials.gov/show/NCT00581399 Completed University of California, Irvine 2010-07-31
NCT00377871 Hemodynamic Performance in Stentless Heart Valves https://ClinicalTrials.gov/show/NCT00377871 Completed University of Aarhus 2010-01-31
NCT00371891 Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS) https://ClinicalTrials.gov/show/NCT00371891 Completed St. Joseph’s Healthcare Hamilton 2009-06-30
NCT00370643 Glucose Control in Open Heart Surgery https://ClinicalTrials.gov/show/NCT00370643 Completed University of Sao Paulo NA
NCT00356759 Prolongation of the Interval Between Monitoring of Warfarin in Stable Patients https://ClinicalTrials.gov/show/NCT00356759 Completed McMaster University 2010-01-31
NCT00329667 Observational Study of Prosthetic Tissue Aortic and Mitral Heart Valve https://ClinicalTrials.gov/show/NCT00329667 Completed Abbott Medical Devices 2006-03-31
NCT00291525 Randomized On-X Anticoagulation Trial https://ClinicalTrials.gov/show/NCT00291525 Active, not recruiting On-X Life Technologies, Inc. 2020-12-31
NCT02833948 Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT) https://ClinicalTrials.gov/show/NCT02833948 Completed ECRI bv 2018-12-31
NCT00166400 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. https://ClinicalTrials.gov/show/NCT00166400 Completed Mayo Clinic 2007-07-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03376165 Post-Operative Myocardial Incident & Atrial Fibrillation https://ClinicalTrials.gov/show/NCT03376165 Recruiting University Hospital, Lille 2028-01-31
NCT03826264 Transpacific TAVR Registry https://ClinicalTrials.gov/show/NCT03826264 Recruiting Asan Medical Center 2022-12-31
NCT03248232 Assessments of Thrombus Formation in TAVI https://ClinicalTrials.gov/show/NCT03248232 Completed Kumamoto University 2018-04-30
NCT03239509 15 Years Outcomes Following Bioprosthetic vs Mechanical Aortic Valve Replacement Between 50-65 Years https://ClinicalTrials.gov/show/NCT03239509 Completed Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud 2018-04-30
NCT03197051 Impact of Perioperative Shedding of the Endothelial Glycocalyx on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery. https://ClinicalTrials.gov/show/NCT03197051 Completed Yonsei University 2018-07-11
NCT03163836 Concomitant Surgical Atrial Fibrillation Ablation in Double Valve Replacement https://ClinicalTrials.gov/show/NCT03163836 Recruiting Guangzhou General Hospital of Guangzhou Military Command 2023-03-10
NCT03139721 Medtronic HAMMOCK Post Approval Study https://ClinicalTrials.gov/show/NCT03139721 Active, not recruiting Medtronic Cardiovascular 2019-05-17
NCT03015025 Pharmacogenetic Dosage Algorithm for Acenocoumarol https://ClinicalTrials.gov/show/NCT03015025 Completed Instituto de Investigación Hospital Universitario La Paz 2013-10-31
NCT02981004 PAR I - Patient-to-Annulus Relation I https://ClinicalTrials.gov/show/NCT02981004 Completed Abbott Medical Devices 2017-12-18
NCT02898090 Development and Validation of Automated Indicators on the Appropriateness of Oral Anticoagulant Prescriptions https://ClinicalTrials.gov/show/NCT02898090 Recruiting University Hospital, Bordeaux 2020-04-30
NCT02790008 Magnetic Resonance Imaging and Fibrosis https://ClinicalTrials.gov/show/NCT02790008 Recruiting Linkoeping University 2019-12-31
NCT02727413 Inflammatory Mediator Profiles During Heart Valve Replacement Surgery https://ClinicalTrials.gov/show/NCT02727413 Completed Jena University Hospital 2017-02-28
NCT02527629 Aortic Replacement Using Individualised Regenerative Allografts - ARISE (the “Surveillance”) https://ClinicalTrials.gov/show/NCT02527629 Completed corlife 2019-01-31
NCT02490644 Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Valvular Heart Surgery https://ClinicalTrials.gov/show/NCT02490644 Completed Yonsei University 2017-09-29
NCT02394184 The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement Registry https://ClinicalTrials.gov/show/NCT02394184 Completed Asan Medical Center 2019-09-24
NCT02371863 Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR https://ClinicalTrials.gov/show/NCT02371863 Completed UMC Utrecht 2015-12-31
NCT02266251 Optimizing Health Outcomes in Patients With Symptomatic Aortic Valve Disease https://ClinicalTrials.gov/show/NCT02266251 Completed Duke University 2017-04-30
NCT02035540 European Clinical Study for the Application of Regenerative Heart Valves - ESPOIR https://ClinicalTrials.gov/show/NCT02035540 Completed corlife 2017-01-31
NCT04454177 SMART Watch Facilitated Early Discharge in Patients Undergoing Transcatheter Aortic Valve Replacement https://ClinicalTrials.gov/show/NCT04454177 Recruiting Second Affiliated Hospital, School of Medicine, Zhejiang University 2021-08-31
NCT01996657 D-Dimer Determined Anticoagulation INTENSITY in Patients With Mechanical Valve Replacement https://ClinicalTrials.gov/show/NCT01996657 Completed Wuhan Asia Heart Hospital 2016-05-31
NCT01760668 Aortopathy in Persons With Bicuspid Aortic Valve, Turner and Marfan Syndrome https://ClinicalTrials.gov/show/NCT01760668 Completed University of Aarhus 2015-10-31
NCT01676727 ADVANCE Direct Aortic Study https://ClinicalTrials.gov/show/NCT01676727 Completed Medtronic Cardiovascular 2014-04-30
NCT01669551 A Phase 1 Feasbility Study Of Volume Intracardiac Echo In Assessment Of Patients With Structural And Valvular Heart Disease Undergoing Percutaneous Transcatheter Therapy https://ClinicalTrials.gov/show/NCT01669551 Completed University of Pennsylvania 2014-12-31
NCT01624870 CoreValve Advance-II Study: Prospective International Post-market Study https://ClinicalTrials.gov/show/NCT01624870 Completed Medtronic Cardiovascular 2013-10-31
NCT01476995 Prognostic Indicators as Provided by the EPIC ClearView https://ClinicalTrials.gov/show/NCT01476995 Completed Epic Research & Diagnostics, Inc. 2011-06-30
NCT01428947 Does Coronary Angiography Cause Cognitive Dysfunction? https://ClinicalTrials.gov/show/NCT01428947 Completed Karolinska Institutet 2012-06-30
NCT01322165 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions https://ClinicalTrials.gov/show/NCT01322165 Completed National Heart, Lung, and Blood Institute (NHLBI) 2015-09-30
NCT04126018 Comparative Imaging Assessment of Valvular Heart Disease https://ClinicalTrials.gov/show/NCT04126018 Recruiting The Cleveland Clinic 2022-06-30
NCT04083118 Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride https://ClinicalTrials.gov/show/NCT04083118 Recruiting University of Edinburgh 2021-08-03
NCT04080219 The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery https://ClinicalTrials.gov/show/NCT04080219 Recruiting Yonsei University 2021-12-31
NCT04068740 Personalised Decision Support for Heart Valve Disease https://ClinicalTrials.gov/show/NCT04068740 Completed German Heart Institute 2019-01-31
NCT04068337 Freestyle Prosthesis for Aortic Root-replacement With and Without Hemiarch Replacement https://ClinicalTrials.gov/show/NCT04068337 Completed Triemli Hospital 2019-03-01
NCT04067635 Primary Mitral Regurgitation Repair https://ClinicalTrials.gov/show/NCT04067635 Enrolling by invitation The Methodist Hospital System 2021-06-30
NCT04024566 Rapid Non-invasive Detection of Aortic Stenosis https://ClinicalTrials.gov/show/NCT04024566 Recruiting Avicena LLC 2021-05-31
NCT03935178 Evaluating Right Ventricular (RV) Size and Function Using the Upper Valley RV Algorithm and Novel Imaging Modalities https://ClinicalTrials.gov/show/NCT03935178 Recruiting Dartmouth-Hitchcock Medical Center 2020-06-30
NCT03836521 Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry https://ClinicalTrials.gov/show/NCT03836521 Recruiting Cedars-Sinai Medical Center 2028-08-15
NCT03724123 Machine Learning-Based Risk Profile Classification of Patients Undergoing Elective Heart Valve Surgery https://ClinicalTrials.gov/show/NCT03724123 Completed Kepler University Hospital 2014-12-31
NCT03669666 Phase Contrast in Valvular Heart Disease https://ClinicalTrials.gov/show/NCT03669666 Completed Assiut University 2018-06-30
NCT03664102 Automated Fastener Device Versus Manually Tied Knot in MiAVR https://ClinicalTrials.gov/show/NCT03664102 Completed Centre Hospitalier La Chartreuse 2018-09-01
NCT03595423 SPAnish Aortic VALVE Multicentric Study https://ClinicalTrials.gov/show/NCT03595423 Recruiting Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud 2019-03-31
NCT03590730 Benefits of ICD for the Primary Prevention in Patients With Valvular Cardiomyopathy https://ClinicalTrials.gov/show/NCT03590730 Recruiting Keimyung University Dongsan Medical Center 2020-11-15
NCT03458806 Phono- and Electrocardiogram Assisted Detection of Valvular Disease https://ClinicalTrials.gov/show/NCT03458806 Active, not recruiting University of California, San Francisco 2020-12-31
NCT03440697 Pathogenetic Basis of Aortopathy and Aortic Valve Disease https://ClinicalTrials.gov/show/NCT03440697 Recruiting Indiana University 2025-12-31
NCT01213615 Hancock II Ultra Porcine Bioprosthesis Hemodynamic Study https://ClinicalTrials.gov/show/NCT01213615 Completed Medtronic Cardiovascular 2013-10-31
NCT01194362 A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve Disease https://ClinicalTrials.gov/show/NCT01194362 Active, not recruiting Baylor Research Institute 2020-12-31
NCT01178502 PGx Study to Develop and Validate the Predictive Warfarin Dosing Algorithm for Personalized Warfarin Pharmacotherapy https://ClinicalTrials.gov/show/NCT01178502 Completed Inje University 2010-04-30
NCT01076296 A Post-Marketing Study for On Label Evaluation of the GE Vscan Ultrasound Imaging System https://ClinicalTrials.gov/show/NCT01076296 Completed GE Healthcare 2012-07-31
NCT01052948 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events https://ClinicalTrials.gov/show/NCT01052948 Completed Pfizer 2009-12-31
NCT03011697 Valvular Heart Disease Registry Study in Second Affiliated Hospital of ZheJiang University https://ClinicalTrials.gov/show/NCT03011697 Recruiting Second Affiliated Hospital, School of Medicine, Zhejiang University 2026-12-31
NCT04445012 Cardiovascular Acoustics and an Intelligent Stethoscope https://ClinicalTrials.gov/show/NCT04445012 Recruiting Papworth Hospital NHS Foundation Trust 2021-09-30
NCT00745810 Anesthetic Management and Remote Reperfusion Injuries https://ClinicalTrials.gov/show/NCT00745810 Completed National Taiwan University Hospital 2010-11-30
NCT00629902 Heart Valve Prosthesis-Patient Mismatch https://ClinicalTrials.gov/show/NCT00629902 Completed Florence Nightingale Hospital, Istanbul 2008-05-31
NCT00412386 Abnormal 3-D MRI Flow Patterns in Adolescents Patients With Bicuspid Aortic Valve https://ClinicalTrials.gov/show/NCT00412386 Completed Emory University NA
NCT00362401 Patients Perception of Mechanical Heart Valve Sounds: Psychoacoustics and Quality of Life https://ClinicalTrials.gov/show/NCT00362401 Completed University of Aarhus NA
NCT00359489 Methods Study to Evaluate Use of Cardiac Ultrasound to Assess Heart Valve Abnormality in People. https://ClinicalTrials.gov/show/NCT00359489 Completed Pfizer NA
NCT00234364 Pergolide Treatment and Valvular Heart Disease https://ClinicalTrials.gov/show/NCT00234364 Completed Ã…rhus Amt NA
NCT00226265 The Short Form-36: Pre- Versus Post-Surgical Administration in Cardiac Surgery Patients https://ClinicalTrials.gov/show/NCT00226265 Completed Weill Medical College of Cornell University 2006-12-31
NCT00202657 Observational Study of Heart Valve Disease in Patients With Parkinson’s Disease Treated With Pergolide https://ClinicalTrials.gov/show/NCT00202657 Completed Société Française de Cardiologie NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03372512 Fluid Status and T1-mapping by CMR https://ClinicalTrials.gov/show/NCT03372512 Recruiting Medical University of Vienna 2020-12-15
NCT03371394 Fluid Status in Valvular Heart Disease https://ClinicalTrials.gov/show/NCT03371394 Recruiting Medical University of Vienna 2020-12-01
NCT02974218 Saint Luc Valve Registry https://ClinicalTrials.gov/show/NCT02974218 Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain 2020-01-31
NCT02925819 Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery https://ClinicalTrials.gov/show/NCT02925819 Recruiting French Cardiology Society 2020-12-31
NCT02806310 Podocan and Wnt Pathway in the Development of Aortopathy in Bicuspid Valve Disease https://ClinicalTrials.gov/show/NCT02806310 Active, not recruiting Bassett Healthcare 2020-06-30
NCT02692833 Telomere Biology and AKI in Cardiac Surgery https://ClinicalTrials.gov/show/NCT02692833 Completed Queen Mary University of London 2017-05-31
NCT02219984 START-Register: Survey on Anticoagulated Patients Register https://ClinicalTrials.gov/show/NCT02219984 Recruiting St. Orsola Hospital 2023-07-31
NCT01823432 Genetic Risks for Bicuspid Aortic Valve Disease https://ClinicalTrials.gov/show/NCT01823432 Recruiting The University of Texas Health Science Center, Houston 2021-05-31
NCT01784055 NeoChord TACT Post-Market Surveillance Registry https://ClinicalTrials.gov/show/NCT01784055 Completed NeoChord 2016-07-31
NCT01756222 Bicuspid Aortic Valve (BAV) Registry https://ClinicalTrials.gov/show/NCT01756222 Recruiting University of Michigan 2030-12-31
NCT04190602 Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System https://ClinicalTrials.gov/show/NCT04190602 Recruiting NeoChord 2021-12-31
NCT04047082 Online Videodensitometric Assessment of Aortic Regurgitation in the Cath-Lab https://ClinicalTrials.gov/show/NCT04047082 Recruiting Imperial College London 2019-09-30
NCT03797820 Multicenter Registry Study of Aortic Valve Stenosis in Zhejiang Elderly(Mrs AVS) https://ClinicalTrials.gov/show/NCT03797820 Recruiting Second Affiliated Hospital, School of Medicine, Zhejiang University 2023-09-30
NCT03709693 Clinical Outcomes in Patients Treated With SternaLock Blu https://ClinicalTrials.gov/show/NCT03709693 Recruiting Zimmer Biomet 2026-01-01
NCT03674788 The Prospective LEUVEN Transcatheter Valve Therapy Registry https://ClinicalTrials.gov/show/NCT03674788 Recruiting Universitaire Ziekenhuizen Leuven 2037-12-31
NCT03488732 Valvular Heart Disease Registry https://ClinicalTrials.gov/show/NCT03488732 Recruiting Technische Universität München 2025-01-01
NCT03488420 Canadian EdoxAban(Lixiana®) Registry in Patients With ATrial Fibrillation/Flutter With Confirmed ValvUlar HeaRt DiseasE https://ClinicalTrials.gov/show/NCT03488420 Recruiting Montreal Heart Institute 2021-03-01
NCT03484806 Registration and Cohort Study of Valvular Heart Disease in Adults in China https://ClinicalTrials.gov/show/NCT03484806 Recruiting China National Center for Cardiovascular Diseases 2020-09-01